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ErythronDB

The Erythron Database (ErythronDB) was a resource dedicated to facilitating better understanding of the cellular and molecular underpinnings of mammalian erythropoiesis. It provided a searchable database of murine gene expression during murine primitive, definitive, and stress erythroid cells at progressive stages of maturation. ErythronDB also allowed users to explore the role of erythropoietin (the principal hormone regulating erythropoiesis) and identify potential targets of EPO-signaling via comparison of rhEPO-treated versus control cells in mouse (microarray expression) and human (proteomics) datasets.

ErythronDB was developed by a team of researchers at the University of Pennsylvania. Code for generating the web site is available at https://github.com/ErythronDB/erythrondb-docker

Datasets in ErythronDB

Ontogeny of erythroid gene expression

EPO-regulated targets in murine erythroid progenitors

EPO-regulated targets in murine E1 cells with a truncated erthropoietin receptor (EpoR)

EPO phosphorylation PTM targets in UT-7epo-E cells

To Cite this Resource

Kingsley P.D., Greenfest-Allen E., Frame J., Bushnell T., Malik J., McGrath K.E., Stoeckert C.J., and Palis J. Ontogeny of erythroid gene expression. eBlood. 2012. PMID: 23243273

Funding

National Institute of Diabetes and Digestive Kidney Diseases (Erythroid Lineage Molecular Toolbox); NIDDK R01 DK 071116